Development, Feasibility, and Acceptability of a Nationally Relevant Parent Training to Improve Service Access During the Transition to Adulthood for Youth with ASDRandomized Controlled Trial Published on 2022-06-012022-10-05 Journal: Journal of autism and developmental disorders [Category] 임상, [키워드] acceptability access adulthood ASD autism spectrum Autism Spectrum Disorder COVID-19 development disorder effective Families feasibility feasible implication Intervention parent participant Participants randomized-controlled Result service services suggested trade-off training transition Transition to adulthood. Treatment Trial Youth [DOI] 10.1007/s10803-021-05128-z PMC 바로가기 [Article Type] Randomized Controlled Trial
The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use칸나비노이드 수용체-1 유전자는 스트레스가 많은 생활 사건과 상호작용하여 문제가 있는 알코올 사용의 위험을 증가시킵니다Article Published on 2022-03-232022-09-11 Journal: Scientific Reports [Category] 변종, [키워드] Activation adulthood Affect alcohol Alcohol Use Disorders Identification Test association Audit baseline binding Brain childhood CNR1 conducted COVID-19 pandemic Cross-sectional analyses cross-sectional analysis death develop disorders DNA event Evidence Factor functional Genetic variant genetic variants Genome-wide association study genotyped habituation humans identification identify implicated interact Interaction interactions Model Neuroticism not significant nucleotide outcome outcomes Personality Trait polymorphism predicted predictor provided Psychiatric public health reason for receptor repeated reported Research risk risk allele single nucleotide Single nucleotide polymorphism SLE Stress Stressor stressors substance Substance use substance use disorders Support Swedish targets Test traits Treatment turn [DOI] 10.1038/s41598-022-08980-w PMC 바로가기 [Article Type] Article
Paternally expressed gene 3 ( Pw1/Peg3 ) promotes sexual dimorphism in metabolism and behavior친밀하게 발현 된 유전자 3 (PW1/PEG3)은 신진 대사와 행동에서 성 이형성을 촉진합니다Research Article Published on 2022-01-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerated Adiposity adulthood age allele alteration Behavior Brain Cell cells Characteristics consequence contribute develop Diabetic Endocrine Epigenetic examined expressed expressing fat accumulation Fatty liver female genomic genomic imprinting gonadal growth hormone insulin insulin resistance life loss of function male mammal mammals manifested masculinization metabolism mice mutant observation parental pathway Peg3 phenotypic postnatal development proliferative promote provide puberty question reduced Regulation selective Sex sex steroid sexual dimorphism Signaling steroid Support tissues weaning [DOI] 10.1371/journal.pgen.1010003 PMC 바로가기 [Article Type] Research Article
Loneliness among Middle-Aged and Older Middle-Aged Adults in Russia (Saint Petersburg) before and during COVID-19 PandemicArticle Published on 2021-09-202022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] activated activities adjust adulthood age analysis caused change changes in Characteristics collected complex conducted COVID-19 COVID-19 pandemic demographic data domains Effect Emotional loneliness environmental factors expected groups increase in inventory Isolation loneliness males mechanism Modification Older pandemic participant physical positive loneliness predicted Regression reported Russia Saint Petersburg scale solitude would increase [DOI] 10.3390/ijerph18189889 PMC 바로가기 [Article Type] Article
Early life predictors of positive change during the coronavirus disease pandemicResearch Published on 2021-05-182022-10-28 Journal: BMC Psychology [Category] COVID-19, SARS, [키워드] adaptive adulthood assessments association census Child Care childhood Cohort Combination coronavirus disease Coronavirus disease pandemic COVID-19 COVID-19 pandemic determine develop development dysfunction early life adversity effort event Evidence examination female finding growth Impact impacts implication increases in independent individual inventory Neighborhood disadvantage notable pandemic participant positive Positive change predict predicted predictor Protective reduce Regression analyses Resilience response Result self-report questionnaire Sociodemographic factor socioeconomic status Stress subset tested were assessed Youth [DOI] 10.1186/s40359-021-00586-7 PMC 바로가기 [Article Type] Research
Cognitive flexibility and perceived threat from COVID-19 mediate the relationship between childhood maltreatment and state anxietyCOVID-19의 인지 유연성과 인지된 위협은 아동 학대와 국가 불안 사이의 관계를 중재합니다Clinical Trial Published on 2020-12-112022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] ACEs adaptive adulthood Adults Adverse Adverse Childhood Experiences Scale Alter Anxiety anxiety levels appraisal childhood cognitive cognitive flexibility COVID-19 dysfunction early life adversity empirical evidence Evidence examined experience exposure to flexibility health problems highlight implicated indicate individual life mental health problem mental health problems Psychological reduced regression analysis scale Stressor stressors turn [DOI] 10.1371/journal.pone.0243881 PMC 바로가기 [Article Type] Clinical Trial
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits아동기 체질량 지수에 대한 새로운 유전자좌 및 성인 심장 대사 특성과 유전성을 공유Research Article Published on 2020-10-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adult diseases adulthood age analyses association biological processe biological processes Birth weight BMI body mass body mass index cardiometabolic trait childhood children Complete correlation diabetes Diastolic blood pressure disease Evidence explained Factors Genetic genetic background genetic factors Genetic variant genetics Genome-wide association study genome-wide significance implicated independent involved loci menarche Meta-analysis Metabolic diseases NEDD4L novel outcome overlap overlapping P-value p-values performed phenotype phenotypic reached Replication reported shown SLC45A3 type 2 diabete type 2 diabetes waist waist-to-hip ratio [DOI] 10.1371/journal.pgen.1008718 PMC 바로가기 [Article Type] Research Article
Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cellsB 세포 발달 동안 비활성 X에서 Xist RNA의 손실은 활성화된 B 세포에서 동적 YY1 종속 2단계 과정으로 복원됩니다.Research Article Published on 2017-10-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation adulthood Autoimmune disorders Autoimmunity B cell B cells Cell change chromatin chromosome compensated Critical develop DNA DNA binding domain dosage ectopic expression embryogenesis Epigenetic Ex vivo expression female Genes Genetic heterochromatin Immunity impair inactivation inactive indicate lack Lineage Loss lymphocyte Lymphocytes mechanism Modification modifications pathogenic pattern Recombination regulate regulated restored reveal RNA Stimulation susceptibility transcription factor up-regulation X-linked X-linked gene YY1 Zinc [DOI] 10.1371/journal.pgen.1007050 PMC 바로가기 [Article Type] Research Article
Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasisZebrafish slc30a10 결핍은 망간 항상성을 유지하는 Atp2c1의 새로운 보상 메커니즘을 밝혀냈습니다Research Article Published on 2017-07-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accompanied accumulated activating adulthood approach ATP2C1 ATPase Author Brain can be used characterized cirrhosis cirrhosis) clinically CRISPR deficiency degenerative degenerative diseases develop disease Disease model disorder dysregulation dystonia early-onset EDTA effective Embryo embryonic ENCODE expressing expression fibrosis form HeLa cells hepatic injury homeostasis Impaired impaired function implicated inhibit iron liver Liver fibrosis manganese manganism mechanism metabolic disorder metabolism modulating mutant mutant embryo mutant embryos mutants Mutation neurological Neurological deficit neurological deficits neurological impairment pharmacological phenotype physiological polycythemia recent reduce rescued secretory pathway Signaling significantly higher SLC30A10 specific treatment steatosis therapy underlie wild-type zebrafish [DOI] 10.1371/journal.pgen.1006892 PMC 바로가기 [Article Type] Research Article
Adolescent booster with hepatitis B virus vaccines decreases HBV infection in high-risk adultsArticle Published on 2017-02-152023-06-18 Journal: Vaccine [Category] B형 간염, [키워드] Adolescent booster adulthood Hepatitis B virus Maternal HBsAg status vaccination. [DOI] 10.1016/j.vaccine.2016.12.062 PMC 바로가기